腈脱水制备酸

unnel and extracted with diethyl ether (3 × 50 mL). The combined organic extracts were washed with water (60 mL) and dried over sodium sulfate (25 g). After filtration, the solvent was removed by rotary evaporation, and the yellow liquid residue was

distilled under reduced pressure to afford 2-phenylpropionic acid (14.3 g, 93%) as a pale-yellow liquid.

Reference: Organic Syntheses Coll. Vol. 10, 640

3 、亚硝乙酸钠促进的吡啶的乙酸溶解示例

A mixture of compound 1 (6.6 g, 35 mmol), conc. H2SO4 (29 ml), AcOH ( 58 ml) and water (115 ml) was heated at 120°C for 1h, then a solution of NaNO2 (4.0 g), in water (30 ml) was added at 90~100°C. After the mixture had been heated for 1 h, NaCl (40 g) was added to the hot mixture and the whole was cooled in an ice-bath. The precipitate was collected to give the crude free acid (6.2 g, 62%).

本文细节意指互联，版权归原作者所有。

吡啶在硫乙酸/乙醇中都冷却回流可以从外部得到也就是说的乙烯。

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